It is insoluble in water and is commercially prepared in propylene glycol. The onset of action is relatively rapid, but the duration of action is 2-4 hours.It is metabolized almost exclusively in the liver; therefore, this drug should not be used in patients with cirrhosis.When the p H is less than 4, it is water soluble and the chance of pain at the injection site is lowered.Unlike other benzodiazepines, midazolam becomes lipophilic at a p H greater than 4.One of the most important goals of clinicians is patient comfort.When patients present to the emergency department (ED), treating the pain and anxiety that accompany the chief complaint are critical to patient satisfaction and quality of care.
gratis paren datingsite
This determines the equipment that one should have readily available prior to starting the procedure.
Benzodiazepines differ by the methods they can be given, time of onset, action duration, mechanism of metabolism, and presence of active metabolites.